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Liver Cirrhosis

Liver cirrhosis is a progressive and irreversible condition characterized by the scarring of the liver tissue. This scarring replaces healthy liver cells with fibrous tissue, impeding the liver’s ability to function properly. As the damage accumulates over time, the liver loses its capacity to perform vital functions, such as detoxifying the blood, producing essential proteins, and aiding in digestion.

Diagnosis for Cirrhosis

The diagnosis of cirrhosis typically involves a combination of medical history, physical examination, and diagnostic tests. A healthcare provider may inquire about symptoms, alcohol consumption, and any relevant medical history. They may also perform a physical examination to assess for signs and symptoms of liver cirrhosis, such as fatigue, ascites, and easy bruising and bleeding.

 

Blood Tests (Liver function tests)

One crucial aspect of cirrhosis diagnosis involves analyzing liver function through blood tests. These tests measure the levels of enzymes and proteins produced by the liver. Elevated levels of certain enzymes, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), may indicate liver damage. Additionally, assessing the levels of bilirubin, albumin, and international normalized ratio (INR) helps evaluate the liver’s synthetic and metabolic functions.

These blood tests provide valuable insights into the overall health of the liver and help identify the extent of damage caused by cirrhosis. Regular monitoring of these blood markers is essential for managing the condition effectively.

 

Imaging Studies (CT scan, MRI)

A CT scan utilizes X-rays to create detailed cross-sectional images of the liver. It helps identify the presence of scar tissue, nodules, or any abnormalities in the liver structure. This imaging technique is particularly useful for assessing the overall condition of the liver and detecting complications associated with cirrhosis.

MRI, on the other hand, uses magnetic fields and radio waves to generate detailed images of the liver. It provides a clearer view of the liver’s internal structures, aiding in the identification of cirrhosis-related changes. MRI is especially valuable for evaluating blood flow within the liver and detecting abnormalities that might not be visible through other imaging methods.

 

Liver Biopsy

In some cases, a liver biopsy may be recommended for a more detailed analysis of the liver tissue. During a liver biopsy, a small sample of tissue is extracted for examination under a microscope. This invasive procedure allows healthcare professionals to assess the degree of scarring and inflammation present in the liver. While a liver biopsy provides valuable information, it is usually reserved for cases where other diagnostic methods are inconclusive or when additional details are needed to plan treatment effectively.

 

Treatment Options for Cirrhosis

Managing cirrhosis involves addressing complications and, in severe cases, considering liver transplantation. By understanding the causes, symptoms, and diagnostic methods for cirrhosis, individuals and healthcare professionals can work together to formulate an effective plan of treatment for cirrhosis caused by fatty liver and to improve the quality of life for those affected. Regular monitoring and adherence to medical advice remain essential for optimal management of this complex condition.

 

Management of Complications (Ascites, Variceal Bleeding)

  • Ascites: The buildup of abdominal fluid can be managed through dietary sodium restrictions and medications to promote fluid elimination. In severe cases, procedures like paracentesis may be necessary to drain excess fluid.

 

  • Variceal Bleeding: Enlarged veins in the esophagus can bleed, posing a significant risk. Medications to reduce pressure in the veins (beta-blockers) or endoscopic procedures may be employed to prevent or stop bleeding.

 

Liver Transplantation

Liver transplantation is a definitive treatment for advanced cirrhosis when the liver is severely damaged and no longer functions adequately. It involves replacing the diseased liver with a healthy one from a deceased or living donor. Here’s a more in-depth look at liver transplantation:

  • Evaluation: Before a transplant, thorough medical and psychological evaluations are conducted to assess the patient’s overall health and determine if they are a suitable candidate.

 

  • Waiting List: Patients in need of a liver transplant are placed on a waiting list. The allocation of donor organs is based on factors such as severity of illness, blood type, and organ size.
  • Surgery: The transplantation surgery is a major procedure that typically takes several hours. The diseased liver is removed, and the new liver is carefully implanted.

 

  • Recovery: Following transplantation, patients require extensive post-operative care. Immunosuppressive medications are prescribed to prevent rejection of the new liver.

 

  • Life After Transplant: While liver transplantation offers a chance for a healthier life, it comes with ongoing medical management, including regular follow-up appointments, medication adherence, and lifestyle modifications.

Liver transplantation has shown remarkable success in improving the quality of life for individuals with advanced cirrhosis. However, the availability of donor organs and the complexities of the procedure make it a consideration for those with severe liver damage who have exhausted other treatment options. Remember, awareness of liver failure stages is crucial to determining the appropriateness of transplantation.